Linzess is a prescription medication used to treat persistent constipation (also known as chronic Irritable Bowel Syndrome (IBS) for people who suffer from constipation as a primary symptom.
Linzess (Linaclotide), which increases chloride and water secretion within the intestines, helps to soften stool and stimulate bowel movements.
Linzess (Linaclotide), an agonist, triggers the guanylate cyclase 2C cell surface receptor (GC–C). The drug attaches to the epithelial cells in the intestine’s mucosa. Even at therapeutic levels, Linaclotide is not well absorbed and is difficult to trace in the circulatory system. The body’s cyclic guanosine monophosphate (cGMP) level increased when GC-C was activated.
Linaclotide may also be thought to reduce the excitability of colonic sensory neurons, which can alleviate pain and stimulate colonic motor neurons, increasing smooth muscle contraction and promoting digestion.
It may take up to 2 weeks for your signs to improve. Keep taking the medication exactly as directed, and contact your doctor if you don’t see improvement within a few days.
To preserve its effectiveness, keep it at room temperature, away from heat and moisture. Keep the original container with the moisture-absorbing preservatives packet and tablets.
Children should not take or give this medication. Linaclotide can be dangerous for children if they inadvertently take it.
What is Linzess’ work like?
Linzess accelerates bowel movements. It is still achieved by a series of actions that eventually increase chloride and carbonation in the intestinal intestines. This increases the amount of fluid within the intestines.
Food transit becomes faster and more accessible throughout the GI tract. Linzess may also calm pain-sensing nerves. This was only confirmed in animal studies. Its relevance for humans is not yet proven or documented.
Linzess Pros and Cons
- Linzess (Linaclotide) acts locally and is not absorbed. It does not enter the systemic circulation and has no systemic adverse effects.
- Linzess (Linaclotide) reduces constipation through improved gut motility, stool water, and movement. Because it has a dual effect, Linzess (Linaclotide) is more effective than any other medication used to treat constipation.
- Linzess is a laxative that reduces constipation but also works on the local nerve endings to relieve IBS and visceral discomfort. If interested, please check this article: Bluna Kids – KF94 Review.
Cons of Linzess:
- Linzess is still considered to be a safe drug. However, it can cause severe diarrhea and dehydration, especially in children under six.
- It is not recommended for use by anyone under 18 years old and is strictly prohibited in children under six years of age.
- Children as young as three years old may have severe diarrhea. This can lead to dehydration. These children may have to be admitted to the hospital for intravenous fluid therapy to prevent hypotension and renal damage.
Linzess Side Effect
Diarrhea is still the most common side effect reported by Linzess users. It affects approximately 16 to 20% of Linzess users. This means that roughly one-fifth of Linzess users will experience diarrhea.
Linzess users who have experienced it in the past two weeks are at risk. Particularly those taking the 145 or 290 microgram capsules. This type of diarrhea is still considered severe and severe. It can sometimes cause electrolyte imbalances, such as low potassium. If you experience simple diarrhea after treatment with Linzess, you should call your surgeon immediately.
Linzess can also cause side effects.
Linzess Flatulence and gas are associated with abdominal pain in approximately seven percent of patients. This is compared to four to six percent for the rest. Abdominal distension refers to the sensation of pressure or fullness in your abdomen. About one to three percent of people experience it. It can also be called gastroesophageal reflux and sometimes vomiting.
When is Linzess (Linaclotide) best to take?
Linzess (Linaclotide) should be taken once daily, with an empty stomach, at a minimum of 30 minutes before breakfast. You should not take Linzess (Linaclotide) with any meal, mainly if it contains high amounts of fat. This can cause diarrhea.
What should I do if I forget to take Linzess (Linaclotide), and I’m not sure what to do?
You can skip a missed dose and take your average amount the next day. Do not take two doses at once, as this could cause diarrhea or stomach upset.
How long does it take for diarrhea to occur after Linzess (Linaclotide)?
Linzess (Linaclotide) is often reported to have side effects like diarrhea. It usually occurs within the first two weeks after taking the medication. If the diarrhea is severe enough, it can lead to dehydration. This can cause confusion, dizziness, fainting, and racing hearts. Drink plenty of fluids to prevent severe dehydration while taking Linzess or Linaclotide. If you have severe diarrhea, such as sudden stomach pains or stool that looks like tar or is very reddish or yellowish, consult your doctor immediately.
What time does Linzess (Linaclotide) take to start working?
In about one week, Linzess (Linaclotide) can help relieve constipation and IBS symptoms (painful, bloating, and discomfort). Your stomach symptoms will improve with continued use.
Does LINZESS cause weight loss?
Linzess does not cause weight gain or loss. However, it can cause diarrhea which may, in some cases, lead to weight loss. Linzess can also cause bloating, which could lead to weight gain.
Linzess (linaclotide), is it a laxative?
Linzess (linaclotide), is not a laxative. Bulk, osmotic, stool softeners, and stimulant laxatives are all used to manage occasional constipation. They are only used when necessary. Linzess (Linaclotide), a guanylate cyclase C (GC-C) agonist, is approved for once-daily management of long-term constipation.
Can Linzess cause liver damage?
Linaclotide, a minor peptide antagonist of the guanylate-cyclase A receptors in your intestine, is taken orally to treat chronic constipation. There have been no reports of Linaclotide-related serum enzyme elevations or clinically evident liver injury episodes.
Linzess is still contraindicated for children under six years of age. This means it should be stopped from being given to children below six. Linzess is not recommended for children aged 6-18 as it could potentially cause harm.